By the end of this section, you will be able to:

Define genomics
Describe genetic and physical maps
Describe genomic mapping methods

I am making some changes to this module, but I am not publishing By the end of this section, you will be able to:Describe three types of sequencingDefine whole-genome sequencing

By the end of this section, you will be able to:

Explain how the structure of DNA reveals the replication process
Describe the Meselson and Stahl experiments

By the end of this section, you will be able to:

Discuss the different types of mutations in DNA
Explain DNA repair mechanisms

By the end of this section, you will be able to:

Discuss the similarities and differences between DNA replication in eukaryotes and prokaryotes
State the role of telomerase in DNA replication

By the end of this section, you will be able to:

Explain the process of DNA replication in prokaryotes
Discuss the role of different enzymes and proteins in supporting this process

By the end of this section, you will be able to:

Describe the structure of DNA
Explain the Sanger method of DNA sequencing
Discuss the similarities and differences between eukaryotic and prokaryotic DNA

By the end of this section, you will be able to:

Explain transformation of DNA
Describe the key experiments that helped identify that DNA is the genetic material
State and explain Chargaff’s rules

By the end of this section, you will be able to:

Describe how changes to gene expression can cause cancer
Explain how changes to gene expression at different levels can disrupt the cell cycle
Discuss how understanding regulation of gene expression can lead to better drug design

By the end of this section, you will be able to:

Explain the process of epigenetic regulation
Describe how access to DNA is controlled by histone modification

By the end of this section, you will be able to:

Understand RNA splicing and explain its role in regulating gene expression
Describe the importance of RNA stability in gene regulation

By the end of this section, you will be able to:

Discuss the role of transcription factors in gene regulation
Explain how enhancers and repressors regulate gene expression

By the end of this section, you will be able to:

Understand the process of translation and discuss its key factors
Describe how the initiation complex controls translation
Explain the different ways in which the post-translational control of gene expression takes place

By the end of this section, you will be able to:

Describe the steps involved in prokaryotic gene regulation
Explain the roles of activators, inducers, and repressors in gene regulation

By the end of this section, you will be able to:

Discuss why every cell does not express all of its genes
Describe how prokaryotic gene regulation occurs at the transcriptional level
Discuss how eukaryotic gene regulation occurs at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels

By the end of this section, you will be able to:

List the steps in eukaryotic transcription
Discuss the role of RNA polymerases in transcription
Compare and contrast the three RNA polymerases
Explain the significance of transcription factors